![]() ![]() The bleaching agents whitened teeth compared to placebo over a short time period (from 2 weeks to 6 months), however the certainty of the evidence is low to very low. ![]() 26 studies compared a bleaching agent to placebo and 51 studies compared one bleaching agent to another bleaching agent. We included 71 trials that involved 3780 adults who underwent tooth whitening procedures with various bleaching agents using different methods of application, length of application and duration of treatment. These agents are supplied in different concentrations and are used with different methods of application (gel in tray, strips, paint‐on gel, chewing gum, and mouthwash), which have varying application times and duration of treatment.Īuthors from Cochrane Oral Health carried out this review of existing studies and the evidence is current up to 12 June 2018. A variety of whitening products are available which include hydrogen peroxide, carbamide peroxide, sodium percarbonate, sodium hexametaphosphate, sodium tripolyphosphate, and calcium peroxide. Home‐based whitening products with a bleaching action have become popular and are prescribed to people by the dentist or purchased over‐the‐counter. There has been an increasing demand for whiter teeth. What evidence is available regarding the different home‐based chemically‐induced bleaching agents in whitening teeth? Home‐based chemical bleaching of teeth in adults Tooth whitening did not have any effect on oral health‐related quality of life. Tooth sensitivity and oral irritation were the most common side effects which were more prevalent with higher concentrations of active agents though the effects were mild and transient. ![]() Therefore the evidence currently available is insufficient to draw reliable conclusions regarding the superiority of home‐based bleaching compositions or any particular method of application or concentration or application time or duration of use. Most of the comparisons were reported in single trials with small sample sizes and event rates and certainty of the evidence was assessed as low to very low. In trials comparing one bleaching agent to another, concentrations, application method and application times, and duration of use varied widely. The bleaching agents (carbamide peroxide (CP) gel in tray, hydrogen peroxide (HP) gel in tray, HP strips, CP paint‐on gel, HP paint‐on gel, sodium hexametaphosphate (SHMP) chewing gum, sodium tripolyphosphate (STPP) chewing gum, and HP mouthwash) at different concentrations with varying application times whitened teeth compared to placebo over a short time period (from 2 weeks to 6 months), however the certainty of the evidence is low to very low. Two studies were at low overall risk of bias two at high overall risk of bias and the remaining 67 at unclear overall risk of bias. We included 71 trials in the review with 26 studies (1398 participants) comparing a bleaching agent to placebo and 51 studies (2382 participants) comparing a bleaching agent to another bleaching agent. ![]()
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